Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Cancer

Anti-rheumatic works with anti-cancer drug to boost tumour cell death

Researchers find that auranofin and RAPTA-T can work together to kill tumour cells.

Scanning electron micrograph of a dying cancer cell

Source: Eye of Science / Science Photo Library

Researchers found that the combination of a rheumatoid arthritis drug and an anti-cancer drug increased the overall rate of tumour cell death.

Therapies based on individual drugs often have limited efficacy and poor resistance and safety profiles. Therefore, focus is now being placed on uncovering drug combinations that can work in synergy.

Researchers investigated the potential of two unrelated drugs: rheumatoid arthritis drug auranofin and ruthenium anti-cancer drug RAPTA-T.

RAPTA-T works by forming complexes, called adducts, within the histone proteins that help package DNA, disrupting the DNA and causing the cells to die. The researchers discovered that auranofin binds via an allosteric mechanism within the nucleosome, the part of the cell that contains DNA, and is less likely to form adducts.

However, when used together, RAPTA-T helps auranofin to form these adducts, a synergistic activity that was found to increase the overall rate of tumour cell death.

Reporting their results in Nature Communication (online, 30 March 2017)[1], the researchers conclude that allosteric mechanisms in the nucleosome may have relevance for potential therapies.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202625

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Scanning electron micrograph of a dying cancer cell

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.