Combining nortriptyline with morphine may provide superior analgesia over monotherapies For patients with neuropathic pain, average daily pain scores were reduced significantly more with combination therapy than with either nortriptyline or morphine alone.…
Illicit drug overdose: managing emergency care With up to 253,000 deaths related to drug misuse globally, understanding how to identify and treat drug overdoses can save lives.…
Paracetamol blunts both negative and positive emotionsResearchers have shown that compared with placebo paracetamol blunts emotional responses to both unpleasant and pleasant images.…
High doses of ibuprofen increase cardiovascular risk, EMA warns The European Medicines Agency has confirmed that high doses of ibuprofen and related molecule dexibuprofen carry a small increased risk of cardiovascular diseases.…
Meta-analysis casts doubt over first-line paracetamol use for back pain and osteoarthritis A meta-analysis published in The BMJ has cast doubt on the use of paracetamol as the first-line analgesic for spinal pain and osteoarthritis of the hip and knee.…
FDA fights opioid abuse with industry guidance Measures to limit the abuse of opioid drugs have been issued by the US Food and Drug Administration in guidance for the pharmaceutical industry.…
Review of data casts doubt on use of paracetamol for back pain and osteoarthritis A meta-analysis published in The BMJ casts doubt on the use of paracetamol in spinal pain and osteoarthritis of the hip and knee.…
Reformulated OxyContin reduces abuse but many addicts have switched to heroin Reformulation of OxyContin into an abuse-deterrent formula has reduced its illicit use but has caused people to switch to other opioid drugs, a US study finds.…
Researchers look to spider venom for new analgesics Scientists have identified a potent modulator of voltage-gated sodium (NaV) channels from spider venom, which could hold promise as a new analgesic.…
Paracetamol use linked with cardiovascular risk and other adverse events Researchers have discovered a consistent dose-response relationship between paracetamol use and risk of mortality or cardiovascular, gastrointestinal or renal adverse events.…
