Ebola vaccine based on 2014 virus strain is safe, trial shows

Chinese researchers have developed a recombinant adenovirus type-5 vector-based Ebola vaccine that expresses the envelope glycoprotein from the 2014 epidemic strain. In the image, a scanned electron micrograph of the Ebola virus

Until now, all Ebola virus vaccines have been based on a strain from the Zaire outbreak in 1976, which shares 97.6% similarity with the 2014 west African strain. Taking a new approach, Chinese researchers have developed a recombinant adenovirus type-5 vector-based Ebola vaccine that expresses the envelope glycoprotein from the 2014 epidemic strain.

Two doses of the novel vaccine were evaluated in a randomised, double-blind, phase I study involving 120 healthy adults. The higher dose was safe and “robustly immunogenic” with a 100% response rate and no serious adverse events, the researchers report in The Lancet
[1]
(online, 24 March 2015).

The vaccine will now be evaluated in a phase II trial in outbreak regions. 

References

[1] Zhu F-C, Hou L-H, Li J-X et al. Safety and immunogenicity of a novel recombinant adenovirus type-5 vector-based Ebola vaccine in healthy adults in China: preliminary report of a randomised, double-blind, placebo-controlled, phase 1 trial. The Lancet 2015. doi:10.1016/S0140-6736(15)60553-0.

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Citation
The Pharmaceutical Journal, Ebola vaccine based on 2014 virus strain is safe, trial shows;Online:DOI:10.1211/PJ.2015.20068226