NICE rejects cabotegravir for PrEP in draft guidance Draft guidance said the HIV pre-exposure prophylaxis (PrEP) treatment cabotegravir is not recommended because “it is not possible to determine the cost-effectiveness estimate ... without further analyses from the manufacturer”.…
EMA publishes revised guidelines to reduce risk in first-in-human clinical trials The EMA has released revised guidance to assist sponsors of first-in-human clinical trials with the aim of reducing the risk for participants.…
Financial ties between researchers and the pharmaceutical industry might distort clinical trial results Analyses of data from 195 clinical trials show that financial ties between researchers and the pharmaceutical industry were associated with a 3.57 greater odds of a positive trial outcome.…
Orlistat side effects were underreported, study shows Adverse effects that occurred during clinical trials of Roche’s obesity drug orlistat in the 1990s appear to have been substantially underreported in both published papers and summarised clinical study reports submitted to the European Medicines Agency for drug approval, an analysis has found.…
EMA commits to improving safety of ‘first-in-human’ trials The European Medicines Agency is reviewing its guidelines on first-in-human clinical trials following the death of a patient taking part in a phase I trial in Rennes, France, in January 2016.…
Doxycycline more effective than azithromycin for chlamydia Trial finds doxycycline slightly more effective, but researchers not entirely convinced of its superiority. …
Study supports bypassing weak opioids for strong opioids in cancer pain Most patients given low-dose morphine, a strong opioid, achieved pain reduction of at least 20%, researchers find.…
On-demand prophylaxis protects against HIV infection in at-risk men Randomised trial shows pre-exposure prophylaxis reduced the risk of HIV transmission by 86%.…
Short and sharp radiotherapy as effective as standard radiotherapy for prostate cancer An international study found that giving patients higher but fewer doses of radiotherapy was as effective as standard radiotherapy for prostate cancer.…
New hepatitis C combination treatment effective in HIV coinfected patients Patients with both hepatitis C virus and HIV responded well to daclatasvir combined with sofosbuvir in a study.…
