Cohort study

NSAID prescribing in high-risk groups is a major source of avoidable harm, study finds

The study estimated that the practice could have caused more than 6,000 lost years of good health across England over a ten-year period.…

Combination treatment significantly increases chance of five-year Alzheimer’s survival, study results show

Experts said the large study had found "small but significant effects" of combination treatment with donepezil and memantine in Alzheimer's disease.…

Antipsychotic drugs in dementia treatment associated with range of adverse reactions

Experts say the findings suggest that the risks of prescribing antipsychotics in people with dementia “may be more severe than previously understood”.…

Diltiazem use with anticoagulants associated with higher risk of bleeding compared with metoprolol in older people, study finds

The study included data from 204,155 Medicare beneficiaries in the United States who filled a prescription for apixaban or rivaroxaban between January 2012 and November 2020.…

Protecting our children’s future from global health threats

The pick of the latest academic papers from Parastou Donyai, chief scientist at the Royal Pharmaceutical Society.…

Inflammatory bowel disease may be linked to increased risk of dementia

People with inflammatory bowel disease have a significantly higher risk of developing dementia later in life, a study in Gut has suggested.…

How to understand and interpret clinical data

This resource, part of the acute pain learning series, has been developed to help pharmacists understand the quality of evidence from clinical data to inform the advice they give to patients.…

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Single-pill combination for hypertension linked with improved clinical outcomes and adherence, study finds

Single-pill fixed-dose combination treatment for hypertension improves medication adherence and is linked with a significantly lower risk of heart attack, heart failure or stroke, a study has found.…

Diclofenac and ibuprofen linked to significantly increased risk of cardiac arrest

Having studied data from nearly 30,000 patients with a history of cardiac arrest, researchers conclude that over-the-counter NSAIDs should only be available in pharmacies and at low doses and quantities.…

Proton pump inhibitors may increase risk of first stroke

Data from 244,679 patients that had undergone endoscopy show that stroke incidence was 19% higher in patients who filed a prescription for a PPI compared with those with no PPI exposure…