Interventional studies

Pharmacists are integral to launching more clinical trials in primary care

Why there should be more clinical research in primary care settings and how pharmacists can play a notable role in propelling trials forward.…

Vitamin C ineffective in treating COVID-19 but simvastatin may provide benefit, trial data show

Researchers report that critically ill patients receiving IV vitamin C had a lower hospital discharge rate than those in the placebo group.…

Esketamine outperforms quetiapine for treatment-resistant depression, study finds

Patients with treatment-resistant depression, who received esketamine nasal spray plus an antidepressant, were more likely to achieve remission at eight weeks than those who received quetiapine and an antidepressant, according to trial results.…

Monoclonal antibody treatment for ulcerative colitis twice as effective as placebo, study shows

Of patients with ulcerative colitis who received the monoclonal antibody mirikizumab, 24% were in remission at the end of the trial period, compared with 13% who received placebo.…

Everything you need to know about the COVID-19 therapy trials

There are thousands of clinical trials investigating treatments and preventative measures for COVID-19.…

RECOVERY trial halts recruitment to colchicine arm because of a lack of ‘convincing’ evidence

The anti-inflammatory drug colchicine has shown no significant difference in improving survival rates from usual care in patients with COVID-19.…

New drug cuts the risk of death in bladder cancer by 30% compared with chemotherapy, study suggests

A trial comparing new antibody-drug conjugate enfortumab vedotin with chemotherapy in patients with bladder cancer has found that overall survival was longer in the group receiving the new drug.…

Gout drug could cut length of hospitalisation in patients with moderate to severe COVID-19

Using the gout drug colchicine as a treatment for COVID-19 could reduce the length of both supplemental oxygen therapy and hospitalisation in patients, a small trial finds.…

Critically ill COVID-19 patients unlikely to benefit from convalescent plasma, early results from UK trial show

Results from the REMAP-CAP trial have suggested there is a very low probability that convalescent plasma reduces the number of days in intensive care or death in patients who are severely ill with COVID-19.…

Taking the P: why the founder of P-values would be turning in his grave

How P-values are used today has gradually morphed further and further from their intended use and scientists are now questioning the prominence they are given when interpreting clinical trial data.…