The development and safety of proton pump inhibitors
![Timeline and infographic showing the development and safety of proton pump inhibitors](data:image/svg+xml,%3Csvg%20xmlns=%22http://www.w3.org/2000/svg%22%20viewBox=%220%200%20100%2056%22%3E%3C/svg%3E)
Since the discovery of omeprazole in 1979, dispensing of proton pump inhibitors (PPIs) in England has increased more than 100-fold, and several products are now available without prescription. Although PPIs are effective and generally well tolerated, observational studies suggest an association with…