The development and safety of proton pump inhibitors

Since the discovery of omeprazole in 1979, dispensing of proton pump inhibitors (PPIs) in England has increased more than 100-fold, and several products are now available without prescription. Although PPIs are effective and generally well tolerated, observational studies suggest an association with several adverse effects. Further trials are needed to establish causal relationships. 

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References

Graphics: Alisdair Macdonald.

Sources: Health and Social Care Information Centre, Medicines and Healthcare products Regulatory Agency, Proprietary Association of Great Britain, US Food and Drug Administration, Takeda, Eisai.

Editorial advisers: Emily McDonald, McGill University Health Center, Montréal; Sarah Cripps, Oxford University Hospitals NHS Trust.

 

Last updated
Citation
The Pharmaceutical Journal, PJ, June 2016, Vol 296, No 7890;296(7890)::DOI:10.1211/PJ.2016.20201343