Insulin producing cells transplanted into kidneys of diabetic mice

US researchers have created insulin-producing cells and successfully transplanted them in vivo into the kidneys of diabetic mice. In the image, light micrograph of insulin crystals

Type 1 diabetes is an autoimmune disease that leads to destruction of the pancreatic β-cells. A revolutionary new treatment may be on the horizon after US researchers managed to create human insulin-producing cells (IPCs) that were able to control glucose levels when transplanted in vivo.

Nicholas Zavazava, from the University of Iowa, and colleagues took induced pluripotent stem (iPS) cells from human skin cells and, using a series of pancreatic growth factors, caused them to differentiate into IPCs. The IPCs were then transplanted into the kidneys of diabetic mice, where they were able to secrete insulin and glucagon, to develop their own blood supply and to cause blood glucose levels in the mice to gradually decline.

“iPS cells might be a novel option for the treatment of type 1 diabetes,” the researchers conclude in PloS One (online, 28 January 2015)[1]


[1] Raikwar SP, Kim E-M, Sivitz WI et al. Human iPS cell-derived insulin producing cells form vascularized organoids under the kidney capsules of diabetic mice. PLoS One 2015. doi:10.1371/journal.pone.0116582.

Last updated
The Pharmaceutical Journal, PJ, 21 February 2015, Vol 294, No 7850;294(7850):DOI:10.1211/PJ.2015.20067826

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