Some non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of arterial thrombosis. New findings from a systematic review and meta-analysis suggest that NSAIDs also increase the risk of venous thrombosis.
The study, published in Rheumatology (online, 24 September 2014), included five case–control studies and one cohort study with a total of 21,401 venous thromboembolic events (VTEs). The pooled risk ratio of VTE was 1.8 (95% confidence interval 1.28-2.52) for users of any NSAID and 1.99 (95% CI 1.44-2.75) among users of selective COX-2 inhibitors, versus non-users
The study authors, led by Patompong Ungprasert from Columbia University, New York, note that this is the first meta-analysis to investigate the association between NSAIDs and VTE. “NSAIDs should be prescribed with caution, especially in patients at high baseline risk of VTE,” they warn.
 Ungprasert P, Srivali N, Wijarnpreecha K et al. Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis. Rheumatology 2014. doi: 10.1093/rheumatology/keu408 (accessed 24 September 2014).