NSAID users see an increased risk of venous thrombosis, study shows

Some non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of venous thrombosis, study finds

Some non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of arterial thrombosis. New findings from a systematic review and meta-analysis suggest that NSAIDs also increase the risk of venous thrombosis.

The study, published in Rheumatology (online, 24 September 2014), included five case–control studies and one cohort study with a total of 21,401 venous thromboembolic events (VTEs). The pooled risk ratio of VTE was 1.8 (95% confidence interval 1.28-2.52) for users of any NSAID and 1.99 (95% CI 1.44-2.75) among users of selective COX-2 inhibitors, versus non-users[1]
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The study authors, led by Patompong Ungprasert from Columbia University, New York, note that this is the first meta-analysis to investigate the association between NSAIDs and VTE. “NSAIDs should be prescribed with caution, especially in patients at high baseline risk of VTE,” they warn.

References

 

[1] Ungprasert P, Srivali N, Wijarnpreecha K et al. Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis. Rheumatology 2014. doi: 10.1093/rheumatology/keu408 (accessed 24 September 2014).

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Citation
The Pharmaceutical Journal, PJ, 11 October 2014, Vol 293, No 7831;293(7831):DOI:10.1211/PJ.2014.20066662

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