Researchers find that e-cigarette fluid becomes more toxic during vaping

On culturing lung immune cells with condensed e-cigarette vapour and unvapourised fluid, researchers found that the vapour was toxic at lower concentrations than the fluid and led to greater cell death.

woman vaping e cigarette

Vaping fluid becomes more toxic to cells after it has gone through the vaping process, the results of a study published in Thorax (online, 13 August 2018) show[1]

Researchers cultured alveolar macrophages — a specialised immune cell found in the lungs — with either condensed e-cigarette vapour or with unvapourised e-cigarette fluid.

They found that both e-cigarette vapour and fluid caused a dose–dependent reduction of cell viability but the vapour condensate was cytotoxic at lower concentrations and also led to greater cell death than the unvapourised fluid.

The condensate was also associated with inflammatory responses and a decreased ability of macrophages to destroy bacteria.

The researchers said the findings were important since previous research into the safety of e-cigarettes had considered unvapourised fluid. They noted that several of the effects reported in their study were also seen in cigarette smokers and those with chronic obstructive pulmonary disease.

“While further research is needed to fully understand the effects of e-cigarette exposure in humans in vivo, we suggest continued caution against the widely held opinion that e-cigarettes are safe,” they concluded.


[1] Scott A, Lugg S, Aldridge K et al. Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages. Thorax 2018. doi: 10.1136/thoraxjnl-2018-211663

Last updated
Clinical Pharmacist, CP, December 2018, Vol 10, No 12;10(12):DOI:10.1211/PJ.2018.20205527

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