Seizure disorder suppressed by aromatase inhibitors in rats

Letrozole and fadrozole significantly reduced seizure activity in rat model of status epilepticus.

Researchers Catherine Woolley and Satoru Sato from Northwestern University, Illinois, found that aromatase inhibitors could suppress emergency seizures

Many patients with status epilepticus – a neurological emergency characterised by prolonged seizure – do not respond to currently available drugs and may have to be placed into a pharmacologically induced coma. Therefore, there is a need for acute treatments to manage the condition. 

Researchers from Northwestern University in Illinois studied a rat model of status epilepticus and found that oestrogen production is increased in the hippocampus during seizures. Administration of the aromatase inhibitors letrozole or fadrozole systemically or directly into the hippocampus shortly after seizures significantly reduced seizure activity in both male and female animals. 

Reporting in eLife (online, 14 April 2016)[1]
, the researchers say that the results suggest that clinically available drugs could be effective at suppressing seizures in humans.  


 [1] Sato SM & Woolley CS. Acute inhibition of neurosteroid estrogen synthesis suppresses status epilepticus in an animal model. eLife 2016;5:e12917. doi: 10.7554/eLife.12917

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The Pharmaceutical Journal, Seizure disorder suppressed by aromatase inhibitors in rats;Online:DOI:10.1211/PJ.2016.20201167

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