There is growing interest in using antibiotics to manage acute appendicitis. However, a large randomised controlled trial published in JAMA
[1]
(online, 16 June 2015) failed to meet the required endpoint in enough patients to support the idea.
The Appendicitis Acuta trial enrolled 530 patients with uncomplicated acute appendicitis confirmed by a CT scan. Patients randomised to antibiotics (n=257) received intravenous ertapenem for three days followed by seven days of oral levofloxacin and metronidazole, whereas patients randomised to surgery underwent standard open appendectomy.
Most antibiotic-treated patients recovered without surgery but 70 underwent appendectomy within one year of initial presentation for appendicitis. Analysis yielded a difference in treatment efficacy between groups of −27.0%, which did not meet the prespecified noninferiority margin for the study. The results should help patients make an informed decision, say the researchers.