CP, March 2018, Vol 10, No 3

Model predicts patient response to antidepressant therapy

Researchers have developed a model to help predict the efficacy of antidepressants for patients with major depressive disorder. …

Lack of evidence to support pharmacological prevention of dementia

It is uncertain whether the lack of evidence supporting the use of pharmacological interventions against dementia is because they are not effective or because of poor trial design.…

Methylphenidate use in pregnancy linked to increased congenital cardiac malformation risk

Researchers say the findings could help inform the risk–benefits of treatment with methylphenidate in early pregnancy…

Warfarin use associated with lower incidence of cancer in people aged 50 or older

A Norwegian cohort study finds that warfarin has broad anticancer potential, which could have implications for medication choice for patients needing anticoagulation…

Evidence for prenatal vitamin D supplementation too weak to make recommendations

A review of data from 43 trials suggests that prenatal vitamin D has positive neonatal outcomes, but the current evidence base does not cover all aspects of outcomes and safety…

Proton pump inhibitor lansoprazole might be effective against tuberculosis

Research published in PLoS Medicine recommends further exploration of the drug to test the findings.…