Implementing chimeric antigen receptor T-cell therapy in practice
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- Question 1 of 15
1. Question
Which of the following groups of medicines are classed as advanced therapy medicinal products?
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2. Question
Tisagenlecleucel and axicabtagene ciloleucel are the two chimeric antigen receptor T-cell (CAR-T cell) treatments licensed in the UK. They can both be used to treat relapsed/refractory diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. Which of the following correctly describes the other licensed indication?
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3. Question
How does a CAR-T cell therapy exert its action?
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4. Question
Doctors, pharmacists and nurses are involved in providing clinical CAR-T cell therapy to patients. Which other setting/discipline is integral to the delivery of CAR-T therapy?
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5. Question
Why is storage and handling of a CAR-T cell therapy best undertaken by stem cell laboratory staff?
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6. Question
Which of the following tasks is undertaken by staff skilled in cellular handling?
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7. Question
Which of the following clinical trials was pivotal in gaining regulatory approval for CAR-T cells?
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8. Question
What is apheresis?
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9. Question
What are the storage conditions for frozen CAR-T cell therapy?
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10. Question
CAR-T cell therapy can cause several toxicities. Which of the following is characteristic of immune effector cell associated neurotoxicity (ICANS)?
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11. Question
Several medicines can be used to aid treatment of cytokine release syndrome (CRS). Which of the following medicines is licensed for this indication?
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12. Question
ICANS can manifest in many ways. Which of these side effects does not necessarily represent neurotoxicity in every case?
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13. Question
The treatment of ICANS involves input from a neurologist and, where appropriate, early transfer to the intensive care unit for monitoring. Which of the following medications can be used to treat one of the symptoms of ICANS?
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14. Question
What dose of tocilizumab is used to treat CRS in adults?
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15. Question
How could CAR-T cell therapy be relevant to a community pharmacist?
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