Prolonged paracetamol use in pregnancy could harm male offspring Pregnant women who take the commonly used analgesic paracetamol for more than a week could lead to reproductive problems in their male offspring, suggests a study.…
Modified yeasts could be used to produce alkaloid drugs Yeast has been genetically modified to make (S)-reticuline, a precursor to a wide range of therapeutic alkaloids. The work marks an important step towards producing such pharmaceuticals by fermentation.…
Ciclosporin fails to demonstrate protection from neuronal damage during thrombolysis The phase II study looked at the potential neuroprotective effect of ciclosporin in 127 stroke patients who also received thrombolysis therapy.…
Combining nortriptyline with morphine may provide superior analgesia over monotherapies For patients with neuropathic pain, average daily pain scores were reduced significantly more with combination therapy than with either nortriptyline or morphine alone.…
Illicit drug overdose: managing emergency care With up to 253,000 deaths related to drug misuse globally, understanding how to identify and treat drug overdoses can save lives.…
Marijuana liquid may play a medicinal role in epilepsy Treatment with cannabidiol reduces seizure frequency for patients with certain epilepsy conditions, research suggests.…
Paracetamol blunts both negative and positive emotionsResearchers have shown that compared with placebo paracetamol blunts emotional responses to both unpleasant and pleasant images.…
High doses of ibuprofen increase cardiovascular risk, EMA warns The European Medicines Agency has confirmed that high doses of ibuprofen and related molecule dexibuprofen carry a small increased risk of cardiovascular diseases.…
Review identifies reporting bias in anxiety disorder trials Trials of antidepressants used to treat anxiety disorders that the US Food and Drug Administration deemed positive were more likely to be published than those deemed negative.…
Meta-analysis casts doubt over first-line paracetamol use for back pain and osteoarthritis A meta-analysis published in The BMJ has cast doubt on the use of paracetamol as the first-line analgesic for spinal pain and osteoarthritis of the hip and knee.…