All patients should undergo pharmacogenetic testing before being prescribed clopidogrel The UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics has highlighted that a significant proportion of the UK population have lower CYP2C19 enzyme levels, which lower the effectiveness of the antiplatelet drug.…
MHRA sets out plans to speed up access to rare disease therapies The Medicines and Healthcare products Regulatory Agency said “the rulebook for rare disease therapies will be overhauled" to make it quicker and easier to get therapies tested and approved.…
Cell and gene therapies could save NHS billions A joint report by the Office of Health Economics and Cell and Gene Therapy Catapult concluded that cell and gene therapies could offer increased productivity and quality of life for patients.…
More than 2,000 patients tested in UK’s first routine genotyping project for clopidogrel prescribing Exclusive: The genotyping project at NHS Tayside identified 2,300 patients, 29% of whom emerged as ‘poor’ or ‘intermediate’ CYP2C19-clopidogrel metabolisers.…
First gene-editing therapy recommended by NICE to treat people with beta thalassaemia NHS England said that around 460 patients aged 12 years and over could benefit from the treatment.…
Screening for gene variants should be broadened to reduce health inequalities, systematic review concludes Study authors have called for an extension to DPYD genetic testing in the UK, to include variants identified in people with African ancestry.…
Targeting better safety: next steps for CRISPR therapeutics Genome editing technique CRISPR was only devised in 2012, but already we have seen the first CRISPR-based medicine for sickle cell disease come to market. Researchers are now refining the technology to improve its safety and efficacy.…
Cystic fibrosis: management and monitoring of respiratory manifestations An overview of the pharmacological management of respiratory symptoms in people with cystic fibrosis to ensure they can optimise benefit from their medication regime.…
Advanced therapy medicinal products: a comprehensive overview for pharmacy professionals An overview of the clinical, institutional, regulatory, safety and economic considerations of advanced therapy medicinal products.…
Medication restrictions for patients receiving CAR-T therapy To assure the quality of CAR-T therapy and optimise the chances of successful treatment, pharmacists caring for CAR-T patients must be aware of the medication restrictions — prior to and following treatment — and their rationale.…
