Asthma and chronic obstructive pulmonary disease (COPD) are common conditions in the UK and inhaled medications are the cornerstone of their management
. Good inhaler technique is essential to maximise the benefits of these medications and improve outcomes for the patient. This article considers the impact of sub-optimal inhaler technique and how healthcare professionals can support patients in optimising their technique.
The goal of asthma treatment is for patients to be symptom free and to be able to lead a normal, active life. More information on asthma, its diagnosis, treatment and management has been covered in previous articles
. The diagnosis, treatment and management of COPD has also been covered in previous articles
. In England and Wales, 45 million prescriptions for inhalers were issued in 2011 at a cost of around £900m
If used correctly, inhalers deliver a smaller effective amount of the drug directly to the site of action in the lungs, with a faster onset of effect and with reduced systemic availability that minimises adverse effects (when compared with systemic administration). Despite this being the preferred method of medication delivery to the lungs, evidence suggests that many patients are unable to use their inhalers effectively
. Although study results vary, estimates of inhaler errors include up to 90% of patients using pressurised metered dose inhalers (pMDIs)
and up to 54% of patients using dry powder inhalers (DPIs)
. Inadequate inhaler technique lowers drug deposition to the lungs, wastes medication and may lead to poor disease control, reduced quality of life, increased emergency hospital admissions and higher treatment costs
. In 2014, the National Review of Asthma Deaths (NRAD) reported that misunderstanding and misuse of inhalers was thought to have contributed to a significant number of the 195 asthma deaths during 2012
. According to the NRAD report, only 49% of patients reviewed in primary care had their inhaler technique checked in the year before their death
. Furthermore, 17% of patients admitted to hospital (n=83) did not have documented evidence that their inhaler technique had been checked during their admission
There is increasing evidence to suggest that correct inhaler technique plays an important role in improving medicine adherence
, clinical outcomes
, quality of life
and use of healthcare resources
. The National Institute for Health and Care Excellence (NICE), England’s health technology assessment body, guideline for patients with COPD
and the British Thoracic Society guideline for asthma
, both recommend that prior to prescribing a new inhaler, the patient should receive training and education in the use of the device. Both sets of guidelines also advise that inhaler technique should be regularly assessed at each clinic visit
. However, recent data suggests that only 7% of healthcare professionals could demonstrate all the correct steps for using a MDI
Correct technique depends on the inhaler type, therefore, patients need to understand the right steps for their own inhaler. It is a good idea for healthcare professionals to learn how to correctly use each inhaler device and to be aware of common errors so they can confidently demonstrate this to patients.
Types of inhaler device
Broadly speaking, there are two classes of inhaler devices
: aerosols, which are either solutions containing medications or suspensions of solid particles in a gas, generated from devices (e.g. pMDIs or breath-actuated pMDI); and DPI delivery devices containing drugs in powdered formulation that have been milled to produce particles in the respirable range. DPI delivery devices allow the particles to be separated by the energy created by the patient’s own inspiratory flow, compared with the pMDI where the device itself generates the energy
. For further information, see ‘Table 1: Advantages and disadvantages of the main inhaler types’. See Figures 1–5 for the range of devices currently available.
|Table 1: Advantages and disadvantages of main inhaler types|
|Reproduced with permission from|
|Metered dose inhalers (MDIs)|
|MDI + holding chamber, reverse-flow spacer or spacer|
|Dry powder inhalers (DPI)|
What are the common problems with inhaler technique and what are their solutions?
Despite the development of several new types of inhaler device over the past 40 years, there has been no sustained improvement in how patients use them
. Initiatives trying to improve patient use of inhalers have included: regular training programmes for patients and healthcare professionals; printed instructional material and videos; measures and devices to make inhalation easier (e.g. the development of a breath-actuated MDI and the attachment of a holding spacer to the MDI); and the design of various DPIs. However, a recent systematic review of inhaler technique concludes that incorrect inhaler technique is unacceptably frequent and has not improved over the past 40 years, indicating an urgent need for new approaches to education and drug delivery
All types of inhaler devices have similar efficacy when tested under strict clinical trial conditions
, however, in the real-life setting of clinical practice, a perfect inhaler does not exist; each has its advantages and limitations (see table 1). For the individual patient, inhalers should not be viewed as equivalent, and device type must become an important variable to consider when planning optimal treatment. Ensuring effective inhalation and drug delivery to the target site depends on many factors, which ultimately impact on patients’ response to treatment. In practice, the choice of inhaler device should not only take device-related aspects (e.g. aerosol velocity) into consideration, but also patient factors (e.g. inhalation flow, dexterity, cognition and preferences). With all inhaler types, error rates increase with age and the severity of airflow obstruction
Incorrect inhaler technique is common, regardless of the type of device prescribed. Patients may be given different inhaler types, receive minimal training (if any) and sometimes receive incorrect training on how to use the device. Therefore, it is important to understand the differences between these two types of inhalers, especially regarding how fast the patient inhales (inspiratory flow)
. The concurrent use of multiple types of inhaler devices with different techniques can confuse patients. Ideally, patients should be prescribed one type of device or, failing that, all aerosols or dry-powder devices so that the same inhalation technique can be used.
Examples of common inhaler technique errors and recommendations for improvement are described in ‘Table 2: Common inhaler technique errors and suggested solutions’.
|Table 2: Common inhaler technique errors and suggested solutions|
|Common error||Explanation and suggested solutions|
|Not shaking an aerosol inhaler device before use||Not shaking the canister properly may lead to inconsistent dosing and poorly functioning inhalers. Shake all inhalers; most dry powder inhalers (DPI) do not need shaking before use.|
|Not priming the aerosol inhaler device||Aerosol inhalers require priming (to check that the spray is functioning) before using for the first time, or if they have not been used for a while (usually five to seven days).|
|Not breathing out before inhaling||Breathing out fully (or as much as is comfortable) reduces the amount of air in the airways and increases the available space for air from the next breath. The result is a deeper than normal inhalation, maximising the opportunity to carry the drug to the site of action.|
|Incorrect positioning of inhaler device|
Patients should be instructed not to hold a DPI with the mouthpiece pointing downwards during, or after loading, a dose, as the drug can escape. It should be kept horizontal or upright.
The patient should keep their chin up or head slightly tilted back when using the inhaler. It should be placed correctly in the mouth and the lips should form a tight seal over the mouthpiece.
|Incorrect coordination of pressured metered dose inhaler (pMDI) actuation with inspiration||To deliver the medication to the lungs from a pMDI, the patient must coordinate breathing in with pressing the canister.|
|Delay in inhaling drug through a holding spacer device (a device when combined with a pMDI helps to improve aerosol delivery)||The medication stays suspended in the spacer for a short time only, so if patients fail to take each dose without delay immediately after loading the spacer, a proportion of the dose is deposited on to the inner surface of the spacer and is therefore lost.|
|Incorrect inspiratory flow rate: breathing in either too fast or too slow||The total lung deposition of an inhaled drug is strongly affected by the speed of inhalation.|
|Not holding your breath after inhalation||The ‘breath hold’ increases lung deposition through the process of sedimentation. By keeping the air still for a few seconds, a greater number of particles will sediment on to the receptor sites because of gravity.|
|Multiple actuations without waiting in between actuations||Very rapid actuations can reduce the dose delivered per actuation.|
|Using an empty inhaler||Patients frequently fail to detect when the inhaler is empty, particularly when using reliever aerosol devices.|
|Poor maintenance of inhaler or spacer device||Spacers should be reviewed every 6–12 months to check that the structure is intact (e.g. no cracks), the outer casing is clean and the valve is functioning.|
How can healthcare professionals talk to patients effectively about inhaler technique?
Training of patients by healthcare professionals has been shown to be an effective means of improving technique
, but it needs to be repeated at intervals, and it is essential that those providing the training are themselves able to demonstrate the correct technique.
A recent study suggested that up to 25% of patients have not received any verbal instruction for the use of their prescribed inhaler
. When given, instruction is often rushed, poor quality and not reinforced. Only an estimated 11% of patients receive follow-up assessment and education on their inhaler technique
. Inhaler technique has been found to deteriorate over time (possibly after as little as two to three months)
, so instruction needs to be repeated at regular intervals. In an Australian study, 75% patients using an inhaler for an average of two to three years reported that they were using their inhaler correctly but, on objective checking, only 10% demonstrated correct technique
Figures 1–5 provide a summary of the techniques for the commonly used inhaler devices, and common errors with patient technique, that healthcare professionals can use as a guide before training patients.
Figure 1. How to use a metered dose inhaler (MDI)
Illustration by Javier Trigo
Figure 2. How to use a metered dose inhaler (MDI) with spacer
Illustration by Javier Trigo
Figure 3: How to use an Accuhaler
Illustration by Javier Trigo
Figure 4: How to use a turbohaler
Source: Illustrations by Javier Trigo
It is a good idea for healthcare professionals to learn how to correctly use each inhaler device (see additional resources for useful videos) and to be aware of common errors (see Table 2 and Figures 1–5), so they can confidently demonstrate this to patients. Healthcare professionals should also learn the rationale for each step of the instructions, so they can clearly explain its importance to patients during counselling (see ‘Box 1: How to engage with patients to confirm inhaler technique’ and ’Box 2: Inhaler technique checklist’).
Box 1: How to engage with patients to confirm inhaler technique
- Introduce yourself to the patient;
- Ask the patient if you can discuss their inhaler treatment with them. Do not ask “Can you use your inhaler?” It is better to say “Can you show me how you use your inhaler so that we can see if we can improve the amount of medicine getting into your lungs?” Do not rely on the patient’s assurance that they know how to use their inhaler; most are unaware that their inhaler technique could be improved;
- It is worth understanding what the patient knows about their lung condition. Educating patients in correct inhaler use may also improve adherence to their treatments;
- Discuss the inhaler with the patient, explaining what medicine it contains and how it should help their lung condition;
- Describe the steps of using the inhaler device (see Box 2 and Figures 1-5);
- Once you have described the steps, show the patient how to do it yourself;
- After you have demonstrated the optimal technique, ask the patient to show you how they would use the inhaler. Check they are doing it correctly and, if needed, explain how they can improve their technique. Non-availability of ample placebo devices can be a barrier to effective education. If a patient has their own inhalers, then an extra dose of these could be given if it is thought unlikely to cause undue harm;
- Ensure the patient knows how to keep their inhaler clean and in good working order. As every inhaler is different, ask the person to follow the manufacturer’s instructions. Also, make sure your patient knows how to recognise that their inhaler is empty or nearly empty;
- Ask the patient if they have any questions or concerns about their medicine and the steps to optimise the delivery to their lungs;
- Repeat instruction regularly. Inhaler technique must be rechecked and education must be regularly reinforced in order to maintain optimal drug delivery.
Box 2: Inhaler technique reminder checklist
- Prepare the device (e.g. remove the mouthpiece cover, open the device, hold the inhaler upright).
- Prepare the dose (e.g. shake all aerosols and load dose for DPIs).
- Breathe out gently as far as is comfortable (not into inhalers).
- Put the mouthpiece in the mouth and close the lips around it.
- Breathe in:
- Check co-ordination of breathing and actuation of MDI
- Think about the type of inhaler device – is it an aerosol device or DPI?
- Breathe in slowly and steadily for all aerosol devices (including through a spacer device).
- Breathe in quickly and deeply for all DPIs
- Remove inhaler from the mouth and hold breath for ten seconds
- Repeat dose (if applicable), replace mouthpiece cover or close device.
- The Greater Manchester Inhaler Technique Improvement Innovation Project, part of Wessex Academic Health Science Network, has produced a number of videos and podcasts on inhaler technique and how to use specific devices, including:
- Asthma UK has also produced guidance on inhaler technique for patients, as well as a number of videos on inhaler technique and how to use specific devices, including:
- Using your inhalers
- Metered Dose Inhaler
- Peak Flow Meter
- EasiBreathe Inhaler
- Small Volume Spacer
- Small Volume Spacer (with a child)
- Large Volume Spacer (single breath)
- Large Volume Spacer (multi-breath)
- Large Volume Spacer (with a mask)
- Large Volume Spacer (with a child)
Anna Murphy is consultant respiratory pharmacist, University Hospitals of Leicester NHS Trust and honorary visiting professor, De Montfort school of pharmacy, Leicester.
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