Whooping cough: public health management and guidance

Pertussis (whooping cough) is a highly contagious, acute bacterial infection. It can affect people of all ages, but is especially dangerous in vulnerable groups, such as unimmunised infants.

Three and a half month-old baby receives DTP vaccination which protects infants from diphtheria, tetanus and pertussis (whooping cough)

Whooping cough (also called pertussis after its causative agent) is a resurgent disease in the UK. A significant increase in observed cases nationally during 2011 led to the declaration of a national outbreak in April 2012[1]
. In 2012, there were 9,367 confirmed cases in England, a ten-fold increase on previous years[2]
. Historically, despite its very high transmissibility, pertussis has been well controlled since the routine introduction of acellular vaccination in 2004, during a period of sustained high vaccine coverage[3]
. There were previous, large epidemics in the 1970s and 1980s owing to drops in vaccine coverage over safety concerns of the previously used whole-cell pertussis vaccine that was introduced in 1952. The recent national increase in observed cases is not unique to the UK and is thought to be partly because of the change in vaccine; acellular versions afford a shorter duration of protection, with less protection again colonisation and, therefore, transmission of bacteria[4]
. Acellular vaccines remain highly effective against infection and severe disease.

Patients infected with the causative agent of whooping cough, Bordetella pertussis, suffer from a prolonged cough illness without fever. Characteristically an illness of older children and adults, it can affect patients of all age groups with severe disease, which includes apnoeic episodes, pneumonia and neurological complications more common in young children, often with high mortality if left untreated. The classic inspiratory ‘whoop’ follows paroxysms of coughing, which begins at week 1–2 of illness and increases throughout the 1–2 months of illness following a 9–10 day incubation[5]
(see Box 1: Clinical symptoms of whooping cough).

Box 1: Clinical symptoms of whooping cough

Whooping cough has three phases of symptoms:

  • 1. The catarrhal phase (lasts around one week)

    • Runny nose.
    • Conjunctivitis.
    • Sore throat.
    • Sneezing.
    • Slightly raised temperature.
  • 2. The paroxysmal phase
    (occurs around one week after catarrhal phase)

    • Intense coughing fits (paroxysms), which tend to last a few minutes at a time and are more common at night. Paroxysms consist of a short expiratory burst followed by an inspiratory gasp (the ‘whoop’ sound). The ‘whoop’ is less common in adults and in children aged younger than three months.
    • Coughing can bring up mucus and may be followed by vomiting.
    • If severe enough, young children may briefly turn blue (cyanosis) if they have trouble breathing because of mucus plugging their airways.
  • 3. The convalescent phase
    (lasts up to three months)

    • The paroxysms will become less severe and less frequent.

UK maternal pertussis vaccination programme

The main aim of the maternal vaccination programme is to boost maternal immunity and optimise the transplacental transfer of maternal pertussis antibodies, so that the neonate has some immunity from birth until they are two months old, when they receive their first pertussis-containing vaccine during their primary immunisation course.

Since the programme’s launch in October 2012 as an outbreak response measure, a pertussis vaccination has been offered to all pregnant women, ideally from 28 to 32 weeks of pregnancy[6]
; this was revised in April 2016 to earlier in pregnancy (from 16 weeks gestation onwards) in order to provide more vaccination opportunities[7]
. The emergency vaccination programme was extended in July 2014 to continue for a further five years based on evidence of the safety and high effectiveness of the programme, with the next evaluation tabled for summer 2019[8]

Since the programme was introduced, there have been 18 deaths in babies from B. pertussis, all born to unvaccinated mothers or those vaccinated immediately before delivery; it takes approximately two weeks for antibody levels to rise[2],[9]
. Annual cases in England have dropped to 4,191 and 5,945 in 2015 and 2016, respectively, although pertussis is cyclical with peaks every three or four years[9]
. The programme has been estimated to be highly effective, preventing over ten years an estimated 1,650 infant hospitalisations, including 55–60 infant deaths, and 20,500 maternal cases, of which 1,800 would be severe. However, the overall cost-effectiveness of the programme will depend on future pertussis incidence[10]
. Recent studies highlight that the vaccine effectiveness of both the UK and United States maternal programmes are above 90%[11],[12]

Maternal immunisation is safe: a review of more than 18,000 vaccinated women in the UK showed no increased risk of adverse pregnancy outcomes, birth complications or time to delivery compared with historical and unvaccinated controls[13]
. One of the potential concerns has been the demonstrated ‘blunting’ in pertussis antibody response to the infants born to vaccinated mothers, although, to date, there has been no translation to any increased risk of disease. Assessing the clinical significance of these findings is challenging given the lack of an agreed correlate of protection. There is also some evidence to indicate an enhancement of the response to tetanus and tetanus-conjugated vaccines, and a decline in response to diphtheria and diphtheria CRM-conjugated vaccines[14],[15],[16],[17],[18]

National guidelines for vulnerable groups

In late 2016, the national guidelines for the public health management of pertussis in England were updated to reflect how the ‘vulnerable groups’ have changed following evidence of the high effectiveness of the maternal vaccination programme[19]
(see Box 2: Vulnerable groups at increased risk of severe or complicated pertussis).

Box 2: Vulnerable groups at increased risk of severe or complicated pertussis

Previously, any child aged under one year who had not completed their primary vaccination programme was considered ‘vulnerable’. In the updated Public Health England guidance, vulnerable infants are now defined according to maternal vaccination, prematurity and age, owing to the limited impact of chemoprophylaxis in the context of high levels of protection conferred through maternal vaccination.

  1. Any child (born < 32 weeks) aged less than two months, regardless of maternal vaccination status.
  2. Any child (born >32 weeks) aged less than two months whose mother was unvaccinated.
  3. Any child aged over two months who is unvaccinated or partially vaccinated (regardless of maternal vaccination status), is considered vulnerable.

Source: Amirthalingam G, The Pertussis Guidelines Group. Guidelines for the Public Health Management of Pertussis in England. Public Health England: London, 2016.

Methods for diagnosis

There are a variety of modalities for pertussis diagnosis depending on the duration of symptoms at presentation and age of the patient.

Polymerase chain reaction (PCR) testing has been rolled out to all Public Health England (PHE) regional laboratories, and has been offered to all age groups (previously only for hospitalised infants aged under one year) since July 2014. PCR is recommended for patients who have only been symptomatic for less than three weeks. Routine culture on special media is available through certain NHS and private laboratories (also for those whose symptoms are present for three weeks or less). Serum samples sent for serology will detect antibodies in patients symptomatic for two weeks or more and are ideal for older children, adults and those presenting later in illness. Oral fluid kits are available from local health protection teams and are aimed at children aged 5–16 years to increase diagnosis in this age group[19]

All suspected cases should be notified to health protection teams before laboratory confirmation.


The UK immunisation schedule contains four doses of pertussis-containing vaccine in childhood, with an accelerated schedule at ages two, three and four months, and a pre-school booster at three years, four months old or shortly after. It does not recommend routine further doses after age ten in individuals who are incompletely immunised, apart from in outbreak scenarios[7]
. The updated recommended groups for post-exposure vaccination are detailed in Table 1. The rationale is to protect vulnerable infants, via those who come into regular contact with them, against any future exposure — this includes close contacts aged over ten years who have not received a pertussis-containing vaccination in the past five years. Children aged under ten years should complete their primary and booster vaccinations as appropriate[19]

Table 1: Groups requiring post-exposure vaccination
Requires post-exposure vaccination Does not require post-exposure vaccination
Unvaccinated mothers exposed after 32 weeks of gestationMothers vaccinated earlier in gestation through the maternity programme
All close family over the age of ten who have not received a pertussis-containing vaccination in the past five years or a DtIP*Babies aged under two months who should complete their primary immunisation schedule 
*Diphtheria, tetanus and inactivated polio vaccine

For maternal pertussis immunisation in the UK national programme, there are two licensed vaccines. Both are acellular pertussis preparations with low-dose diphtheria toxoid, tetanus toxoid and inactivated polio: Repevax® and Boostrix®-IPV. The former was used in the maternal vaccination programme until July 2014, when it switched to Boostrix®-IPV. Despite the switch in vaccine to one with a higher antigen content but fewer antigens (from five to three), overall vaccine effectiveness was maintained at over 90% in the three years following its introduction for laboratory-confirmed pertussis[20],[21],[22]

For infant vaccination, since switching to acellular vaccines in the primary immunisation schedule in 2004, Pediacel® and Infanrix®-IPV+Hib have been used. Both vaccines include diphtheria, tetanus, acellular pertussis, inactivated polio and haemophilus type b conjugates. Pediacel® contains five pertussis components, whereas Infanrix®-IPV+Hib contains three[23]
. They are given to babies at the ages of two, three and four months. From summer 2017, the UK will move to vaccinating infants with Infanrix®-hexa, which will also include protection against hepatitis B[24]

Antimicrobial therapy

Reviews have shown that treatment of pertussis offers little advantage in terms of disease length but should be considered to prevent the spread of B. pertussis to vulnerable contacts who may not have been immunised[25]
. Treatment is most effective when started within 7–14 days of symptom onset but this can be tricky if patients do not present early in their symptom course or there are delays in diagnosis. One UK review stated that there is no evidence of benefit from chemoprophylaxis after 21 days of symptom onset[26]
, with no statistically significant difference in contacts that become culture positive after pertussis exposure when treated with antibiotic chemoprophylaxis[27]

The UK guidelines are conservative in the approach to chemoprophylaxis compared with the United States[28]
, because evidence of efficacy is limited. Furthermore, given the high effectiveness of the maternal immunisation programme, chemoprophylaxis for infants born to vaccinated mothers is unlikely to confer any significant additional protection in the event of an exposure over and above passive protection.

Chemoprophylaxis and treatment of pertussis can prove challenging in women in the first trimester of pregnancy because they can only be prescribed erythromycin, which has been associated with infantile hypertrophic pyloric stenosis, a type of gastric outlet obstruction[29],[30],[31]
. This has been the subject of significant debate[32],[33]
, but the decision to prescribe erythromycin for women in the earlier stages of pregnancy should be clinician-led, based on the likely clinical benefit to the mother and any vulnerable close contacts.

Pregnant women in the third trimester who have been exposed to the disease, but have received a pertussis-containing vaccine between one week and five years ago, do not require chemoprophylaxis.

Within the new PHE guidelines[19]
, the guidelines for chemoprophylaxis have not changed greatly from previous versions (Table 2). Treatment options still include azithromycin, erythromycin, clarithromycin (preferred in neonates) and co-trimoxazole for those unable to have a macrolide. All strains of B. pertussis cultured in the UK are still fully sensitive to treatment but resistance has been noted in the United States, Taiwan and France[34]

Table 2:  Recommended antibiotic therapy 
Age group Clarithromycin Azithromycin Erythromycin
(<1 month)

Preferred in neonates 7.5mg/kg twice a day for 7 days

10mg/kg once a day for 3 days

Not recommended due to association with hypertrophic pyloric stenosisNot licensed for infants <6 weeks

Infants (1–12 months) & children (>12 months)

1 month 11 years:

Under 8kg 7.5mg/kg twice a day for 7 days


62.5mg twice a day for 7 days


125mg twice a day for 7 days


187.5mg twice a day for 7 days


250mg twice a day for 7 days



17 years

500mg twice a day for 7 days


6 months
: 10mg/kg once a day for 3 days


> 6 months:10mg/kg (max 500mg) once a day for 3 days


23 months
: 125mg every 6 hours for 7 days



7 years
: 250mg every 6 hours for 7 days



17 years
: 500mg every 6 hours for 7 days


(doses can be doubled in severe infections)

6 weeks

5 months
: 120mg twice a day for 7 days


6 months

5 years: 
240mg twice a day for 7 days



11 years
: 480mg twice a day for 7 days



17 years
: 960mg twice a day for 7 days

Adults500mg twice a day for 7 days500mg once a day for 3 days500mg every 6 hours for 7 days960mg twice a day for 7 days
Pregnant women2Not recommendedNot recommendedPreferred antibiotic – not known to be harmfulContraindicated in pregnancy

1 Consider if macrolides contra-indicated or not tolerated.

2 For pregnant contacts, a risk assessment would need to be done to look at the risk and benefits of antibiotic therapy/prophylaxis. The aim of treating/prophylaxing women in pregnancy is to prevent transmission to the newborn infant, and should be considered in those who have not received a pertussis-containing vaccine more than one week and less than five years before. Where possible, pregnant women should begin treatment at least three days before delivery.

≠ Doses can be doubled in severe infections.

*Please note that the doses for treatment and prophylaxis are the same.

Source: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/576061/Guidelines_for_the_Public_Health_Management_of_Pertussis_in_England.pdf

Although pertussis is still circulating at levels much higher than was seen pre-2012, the maternal vaccination programme has had significant impact on disease presentation in the most vulnerable infants. The programme will be evaluated in 2019 to determine whether it will be continued. Although post-exposure vaccination and antibiotic prophylaxis are offered to vulnerable contacts (or those who are exposed to them), the most effective intervention mainstay is pre-exposure vaccination. 

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The Pharmaceutical Journal, PJ, May, Vol 298, No 7901;298(7901):DOI:10.1211/PJ.2017.20202721

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