
Shutterstock.com
Women who continue taking olanzapine or quetiapine during pregnancy are more likely to develop gestational diabetes than those who discontinue atypical antipsychotic medication, according to a study in the American Journal of Psychiatry (7 May 2018)[1]
.
The research included data on 1.5 million pregnancies of non-diabetic mothers who had received a prescription for an antipsychotic drug in the 3 months before pregnancy.
The findings showed that women who continued taking olanzapine in the first 20 weeks of pregnancy had a 61% increased risk of gestational diabetes and those who continued taking quetiapine had a 28% increased risk, compared with women who discontinued these drugs.
However, there was no association between continued use of aripiprazole, ziprasidone or risperidone and gestational diabetes.
“Further studies are needed in order to understand the potential effect of switching antipsychotic agents during pregnancy on the risk for gestational diabetes,” said the authors.
“Such information would aid treatment decisions pertaining to women for whom treatment discontinuation is not an option.”
References
[1] Park Y, Hernandez-Diaz S, Bateman B et al. Continuation of atypical antipsychotic medication during early pregnancy and the risk of gestational diabetes. Am J Psych 2018. doi: 10.1176/appi.ajp.2018.17040393
You may also be interested in

Fewer than 20% of type 2 diabetes patients on most effective medicine for them, model shows

ICBs may commission community pharmacies to offer diabetic eye screenings from 2026, says NHS England
