Valbenazine shows efficacy for tardive dyskinesia in phase III trial

Promising results in the search for a drug to treat this involuntary movement disorder.

Molecular structure of valbenazine

Tardive dyskinesia is a term used to describe involuntary movements of the face or body and can be a side effect of chronic exposure to antipsychotics.

In a phase III study, researchers compared the efficacy of a novel treatment for the condition, valbenazine, at two different doses (40 and 80 mg/day), to placebo, in 225 people with moderate or severe tardive dyskinesia.

After six weeks, dyskinesia, as measured by the Abnormal Involuntary Movement Scale, was virtually unchanged in the placebo group at a mean of -0.1 units. A significantly greater decrease was observed in the active treatment groups at a mean of -1.9 units in the 40mg/day group and -3.2 units in the 80mg/day group.

Reporting in the American Journal of Psychiatry
(online, 21 March 2017), the team says the results indicate once-daily valbenazine could be an effective treatment for tardive dyskinesia. It was approved by the US Food and Drug Administration in April 2017.


[1] Hauser R, Factor S, Marder S et al. KINECT 3: A phase III randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia. Am J Psychiatry 2017. doi: 10.1176/appi.ajp.2017.16091037.

Last updated
The Pharmaceutical Journal, Valbenazine shows efficacy for tardive dyskinesia in phase III trial;Online:DOI:10.1211/PJ.2017.20202743

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