CP, December 2018, Vol 10, No 12

Pathophysiology and management of heart failure

Ensuring patients are optimised on maximum tolerated doses of medicines in heart failure with reduced ejection fraction is essential in minimising the burden of the condition.…

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Intravenous fluid management

An introduction to fluid management for adults in hospitals, covering replacement during resuscitation, malnourished patients and following large electrolyte losses.…

Patients are being underdosed: we need new guidance on small-volume drug infusions

Too many patients are not receiving their full prescribed dose with small-volume drug infusions, but hospital pharmacists can act to ensure patient safety.…

Rolling out emergency treatment boxes for bacterial endophthalmitis

Bacterial endophthalmitis is a sight-threatening eye infection, which may occur after penetrating injuries and ocular procedures. Bacterial load in the eye can double within 30 minutes. For this reason, European guidelines recommend delivery of endophthalmitis treatment within one hour of presentati…

New antibiotic effective against multi-drug resistant Gram-negative UTI

A new antibiotic designed to overcome multi-drug resistance is at least as effective as the current standard of care in complicated urinary tract infection, according to trial results published in The Lancet Infectious Diseases.…

More EMA staff expected to move to Amsterdam

The European Medicines Agency will lose fewer staff than feared when it moves from its London headquarters to a new home in Amsterdam after Brexit.…

Anticoagulation: hospital and GP-based pharmacists working together

The pharmacist-led direct oral anticoagulation (DOAC) clinic at Northwick Park Hospital in Harrow, north west London, was set up in April 2017 and sees patients from Brent and Harrow clinical commissioning groups. We run clinics five afternoons per week and typically see between five and eigh…

Durvalumab increases overall survival in stage III non-small-cell lung cancer

The immune checkpoint inhibitor durvalumab significantly improves survival in people with stage III non-small-cell lung cancer, interim trial results published in The New England Journal of Medicine have shown.…

Major study boosts knowledge of blood pressure genetics

A study has found over 500 genetic regions, known as loci, that are associated with blood pressure characteristics and researchers say the information could enable high-risk individuals to be targeted earlier for hypertension prevention.…

Newer hormonal contraceptives still associated with reduced risk of ovarian cancer

Researchers in Denmark found that newer combined hormonal contraceptives were still associated with a reduction in ovarian cancer risk in women of reproductive age.…