Schizophrenia: recognition and management
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Patients with schizophrenia have been shown to have a decreased life expectancy compared with the general population. What is the average reduction in life expectancy?CorrectIncorrect
Schizophrenia is a chronic and debilitating illness that affects approximately what percentage of the population?CorrectIncorrect
Schizophrenia includes a range of symptoms, which are classified as positive, negative and cognitive symptoms. Positive symptoms include:CorrectIncorrect
Clozapine is an antipsychotic that is only licensed for use in treatment-resistant schizophrenia. For treatment-resistant schizophrenia, patients have to be treated with a minimum of how many antipsychotics at an effective dose for an adequate time period?CorrectIncorrect
It is important to treat a patient for an appropriate amount of time and at an adequate dose with an antipsychotic before it is deemed ineffective. How long do the National Institute for Health and Care Excellence guidelines recommend that an antipsychotic is trialled for?CorrectIncorrect
Extrapyrimidal adverse effects (EPSEs) are commonly seen with antipsychotics that strongly antagonise dopamine D2 receptors. Which of the following antipsychotics are most likely to cause EPSEs?CorrectIncorrect
Clozapine can cause serious adverse effects, which can lead to bowel obstruction if left untreated. What is appropriate for initial management of clozapine constipation?CorrectIncorrect
For clozapine to be initiated and continued, what blood tests are required to be carried out at least weekly initially?CorrectIncorrect
Schizophrenia or psychotic symptoms can present in adolescents. Which of the following antipsychotics is licensed for the treatment of psychosis in children?CorrectIncorrect
Long-acting antipsychotics are used to help patients who struggle to take their antipsychotics regularly. Which of the following antipsychotics is available as a long-acting injection in the UK?CorrectIncorrect
It is important that people taking antipsychotics are regularly monitored for several parameters which could help identify potential adverse effects. Which of the following should be monitored weekly for the first six weeks of treatment with any antipsychotic?CorrectIncorrect
Clozapine can cause seizures and, therefore, epilepsy must be appropriately managed before initiating clozapine. Which of the following antiepileptics is contraindicated with clozapine therapy owing to a risk of agranulocytosis?CorrectIncorrect
Which of the following antipsychotics is the most appropriate first choice for a patient who is struggling with weight gain?CorrectIncorrect
A female patient would like to consider having a family in the future. Which antipsychotic is least likely to interrupt her menstrual cycle and therefore may be a suitable choice for her?CorrectIncorrect
Some antipsychotics can cause high prolactin levels as an adverse effect. Which receptor is thought to be the cause of high prolactin?CorrectIncorrect