Treatment of acute and chronic lymphoid leukaemia
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Which is the most common childhood malignancy?CorrectIncorrect
Which of the following treatment choices would be considered as the most appropriate first-line treatment for a 52-year-old fit chronic lymphocytic leukaemia patient with a 17p deletion?CorrectIncorrect
In recent years, our increased understanding of the genetics and molecular biology of chronic lymphocytic leukaemia (CLL) has led to the identification of markers that have prognostic value. Which of the following mutations is associated with a particularly poor prognosis in CLL patients?CorrectIncorrect
In recent decades, much has been learnt about the prognostic features of childhood acute lymphoblastic leukaemia and as a result, a risk-directed approach to treatment has been developed. Which of the following statements is correct?CorrectIncorrect
Which of the following staging systems is widely used in Europe to classify chronic lymphocytic leukaemia patients?CorrectIncorrect
A diagnosis of chronic lymphocytic leukaemia requires an elevated level of lymphocytes in the peripheral blood. Which of the following is the correct minimum cut off when making the diagnosis?CorrectIncorrect
Which one of the following features would not be seen in a child presenting with suspected acute lymphoblastic leukaemia?CorrectIncorrect
Drug management of acute lymphoblastic leukaemia (ALL) and chronic lymphocytic leukaemia has progressed rapidly in the past two decades. Which of the following is an example of a novel agent for the treatment of ALL?CorrectIncorrect
Many patients who are newly diagnosed with chronic lymphocytic leukaemia will not require immediate drug treatment and will be followed on a “watch and wait” basis until their disease becomes more advanced. Which of the following would generally necessitate initiating treatment?CorrectIncorrect
Venetoclax is a novel oral treatment for chronic lymphocytic leukaemia. Although potentially suitable for outpatient administration, patients usually start treatment on an inpatient basis. Which of the following potential toxicities necessitates such an approach?CorrectIncorrect
There are four drugs that are given during remission induction therapy for childhood acute lymphoblastic leukaemia. Which of the following drugs is not used?CorrectIncorrect
Although relatively well-tolerated, ibrutinib has a number of significant side effects. Because of this, it should be used with caution in patients with which of the following co-morbidities?CorrectIncorrect
Prophylaxis with which of the following agents is mandatory for patients receiving treatment with idelalisib?CorrectIncorrect
Which of the following agents might be used as a bridge to haematopoietic stem cell transplantation in relapsed paediatric B-cell acute lymphoblastic leukaemia?CorrectIncorrect
Which of the following is the most common leukaemia in the Western world?CorrectIncorrect