Researchers highlight possible Ebola drug target Scientists have identified an important virulence factor encoded by the Ebola virus, which they suggest could simplify drug development and regulatory approval.…
AstraZeneca’s CRISPR collaborations aim to identify drug targetsAstraZeneca has announced four research collaborations that will use CRISPR, a pioneering genome-editing technique, to identify and validate potential drug targets.…
Study shows how glucocorticoids tightly control the inflammatory response IRAK-M, a key negative regulator of inflammatory pathways, may represent a new therapeutic target to suppress bacteria-induced inflammation, say researchers.…
Human Protein Atlas reveals drug targets The Human Protein Atlas shows the locations of almost 17,000 different proteins in the human body and could offer invaluable guidance for drug developers. …
Sequencing cancer genomes to tailor treatments to individual patients Screening for hundreds of mutations in tumours is the most promising route to customised drug treatments for cancer.…
Immune checkpoint inhibitors bring new hope to cancer patients PD-1 and PD-L1 inhibitors induce a higher response rate across a wider range of tumours than other immunotherapies.…
Forces driving the evolution of biologics into biosimilars and biobetters As demand for biologics increases, manufacturers are devising strategies to maximise their returns on investment and benefit patients.…
Scientific advances are not translating into new cancer drugs, expert warnsThe global system for discovering new cancer drugs is failing to turn scientific advances into innovative new medicines, Paul Workman, interim chief executive of The Institute of Cancer Research in London has warned.…
‘Gene deserts’ are linked with breast cancer, research suggests Single-letter changes within long stretches of non-coding DNA affect how DNA loops together, physically interacting with target genes to influence their expression.…
Gene therapy: a treatment coming of age A decade ago many people had written off gene therapy altogether but now there are dozens of trials in progress around the world.…
