Medicines and Healthcare products Regulatory Agency (MHRA)

Pharmacy bodies warn that demand for weight-loss drug will outstrip supply

Around 220,000 patients could be prescribed Mounjaro in the first three years of the drug's availability to NHS patients in England, the National Institute for Health and Care Excellence has estimated.…

NICE rejects Alzheimer’s disease drugs for third time

The National Institute for Health and Clinical Excellence said the benefits of donanemab and lecanemab in the treatment of Alzheimer's disease are too small to justify their high costs to the NHS.…

MHRA publishes ‘world first’ decentralised manufacturing guidance

The guidance will inform the manufacture of medicines with a short shelf-life or highly personalised medicines at sites within or in close proximity to hospitals.…

Recognising adverse events and using the Yellow Card system

An overview of how to identify, manage and report adverse events.…

Yellow Card reporting in East London NHS Foundation Trust

The Yellow Card scheme is a system for reporting adverse drug reactions (ADRs) from medicines or adverse incidents with medical devices in the UK, ensuring that these products are safe for both healthcare professionals and patients​1–3​. Reporting these issues helps the MHRA to identify new sa…

MHRA urges women taking weight-loss drugs to use effective contraception

Guidance published by the medicines regulator has warned that patients trying to conceive should remain on contraception for a “wash-out” period after stopping GLP-1 receptor agonists.…

MHRA approves ‘world first’ low-carbon version of COPD inhaler

The new version of Trixeo Aerosphere will replace the propellant HFA-134a with HFO-1234ze(E), “a fluorinated gas with near-zero global warming potential”.…

MHRA to review blood monitoring requirements for clozapine patients

Starting in summer 2025, the Medicines and Healthcare products Regulatory Agency will seek views on ways to improve awareness of patient risks related to clozapine.…

Regulators issue warning over prescription-only weight-loss drug advertisements

An enforcement notice has warned that prohibitions include non paid-for content on social media, sponsored searches on search engines and influencer marketing.…

‘Serious gap’ in safe access to medicines for people with sensory impairment, report finds

In a report, the patient safety commissioner for England recommends a funding review to support additional resources to improve access to medicines for those with sensory impairments.…