Paroxetine improves symptoms of heart failure in mice The selective serotonin reuptake inhibitor (SSRI) paroxetine inhibits G-protein-coupled receptor kinase 2, an enzyme that hastens the onset of heart failure.…
Researchers modify peptides from cone snails in quest for neuropathic pain therapy Researchers in Australia have modified peptides from cone snails, which have the potential to provide relief to patients with hard-to-treat neuropathic pain.…
Virus-mimicking TB may offer therapeutic opportunities A study shows that TB bacteria release a section of DNA, a virus-mimicking molecule called c-di-AMP, and its behaviour offers drug and vaccine possibilities.…
Drug candidate eCD4-Ig demonstrates durable protection against HIV infection A drug candidate known as “eCD4-Ig” — a fusion of CD4-Ig with a small CCR5-mimetic sulfopeptide — has efficiently neutralised 100% of a diverse panel of HIV-1, HIV-2 and simian immunodeficiency virus isolates.…
Viral cell entry holds clue to effective treatment of Ebola Scientists have identified an important pathway used by the Ebola virus to gain entry into cells that may lead to new therapeutic approaches.…
Researchers highlight possible Ebola drug target Scientists have identified an important virulence factor encoded by the Ebola virus, which they suggest could simplify drug development and regulatory approval.…
Research challenges ‘cytokine storm’ hypothesis of Alzheimer’s disease Interleukin-10 – an anti-inflammatory cytokine – has detrimental effects in a mouse model of Alzheimer’s disease (AD), challenging the “cytokine storm” hypothesis of AD progression.…
AstraZeneca’s CRISPR collaborations aim to identify drug targetsAstraZeneca has announced four research collaborations that will use CRISPR, a pioneering genome-editing technique, to identify and validate potential drug targets.…
Sestrin 3 gene regulates convulsions in epilepsy Researchers analysed hippocampal brain tissue samples from 129 people with temporal lobe epilepsy and found that genetic control of convulsions was due to a single gene.…
Anti-VEGF therapies could have role in treating TB Bevacizumab, an anti-VEGF drug, was able to normalise granuloma vasculature, improve the delivery of small molecules and decrease hypoxia in a rabbit model of tuberculosis.…