The European Medicines Agency still has a way to go towards clinical trial transparency Loopholes in the new policy on publishing clinical study reports from the European Medicines Agency need to be closed.…
2014: The Pharmaceutical Journal’s news in review Looking back at some of the biggest news stories from the past year. …
Possible role for immune checkpoint inhibitors in glioblastoma Researchers have discovered that brain metastases harbour high densities of tumour-infiltrating lymphocytes, which provide an immunoactive environment.…
Scientists develop promising in vitro blood-brain barrier model Researchers have grown rat brain endothelial cells on one side of a chip and then evaluated the barrier formed by the cells under static and flow conditions.…
Simvastatin induces calcium-dependent apoptosis Simvastatin inhibits proliferation of tumour cells and induces calcium-dependent apoptosis, shows new research published in Journal of Biological Chemistry.…
Metformin shows promise as anti-tuberculosis drug A promising candidate in the search for alternative treatments for Mycobacterium tuberculosis is the antidiabetic drug metformin.…
Lipophilic bisphosphonates used to target lung cancer A new generation of lipophilic bisphosphonates has been designed to target cancer, with a zoledronic acid analogue demonstrating efficacy against lung adenocarcinoma.…
Role for memantine in treating binge-eating disorder Research findings support a role for memantine as a potential pharmacological treatment for binge-eating disorder.…
Forces driving the evolution of biologics into biosimilars and biobetters As demand for biologics increases, manufacturers are devising strategies to maximise their returns on investment and benefit patients.…
Breakthrough in targeting KRAS gene mutation implicated in many cancers Researchers have identified an agent that interferes with the cell signalling protein KRAS and which produces a dose-dependent reduction in tumour growth in a mouse model.…