Pre-clinical research

New drug candidate as strong as morphine without the side effects

PZM21 is as effective as morphine but there is little or no observed respiratory depression or morphine-like reinforcing activity, researchers report.…

Enhanced flu vaccine still doesn’t protect obese mice

Researchers discovered that influenza vaccine adjuvants did not increase response in obese mice.…

Novel antibiotic isolated from human nose

A new antibiotic that can kill MRSAfree has been discovered in the human nose by researchers at the University of Tübingen in Germany.…

Ibuprofen and toremifene inhibit Ebola virus

The surprising results could help guide the development of new Ebola treatments, say the researchers.…

Vaccines developed that completely protect against Zika in mice

Human Zika vaccine should be “readily achievable” following success using flavivirus technique in mice.…

The development and safety of proton pump inhibitors

Since the discovery of omeprazole in 1979, dispensing of proton pump inhibitors (PPIs) in England has increased more than 100-fold, and several products are now available without prescription. Although PPIs are effective and generally well tolerated, observational studies suggest an association with…

How full disclosure of clinical trial data will benefit the pharmaceutical industry

Disclosing clinical trial data is a step in the right direction towards transparency, which benefits both the public and the pharmaceutical industry.…

Developing gene therapy to treat cystic fibrosis: challenges and successes

More than 25 years after the gene for cystic fibrosis was discovered, there are signs that correcting this genetic deficit could soon be possible.…

Q&A: V Craig Jordan — the father of tamoxifen

V Craig Jordan, Dallas/Fort Worth living legend chair of cancer research, professor of both breast medical oncology and molecular and cellular oncology at the University of Texas MD Anderson Cancer Center in Houston, is best known as “the father of tamoxifen”.…

Overcoming the challenges in developing male contraceptives

With several hormonal and non-hormonal male contraceptive candidates in the pipeline, researchers are hoping to ignite interest from a wary pharmaceutical industry.…