Pre-clinical research

Seizure disorder suppressed by aromatase inhibitors in rats

Letrozole and fadrozole significantly reduced seizure activity in rat model of status epilepticus.…

Study shows how proton pump inhibitors damage blood vessel cells

New research into harmful effects of PPIs suggests that the drugs impair vascular cells.…

Search for progressive multiple sclerosis treatment is gathering momentum

There are currently no effective treatments to slow or stop progressive multiple sclerosis (PMS) but recent advances in understanding the complex pathogenesis of the disease, as well as efforts to improve outcome measures, identify biomarkers and refine clinical trial design, mean progress is speedi…

Injected antibodies provide long-term protection against HIV

 Trial results show extended protection against HIV in monkeys treated with monoclonal antibodies.…

Existing drugs are effective against human parainfluenza virus

Study shows that suramin combined with zanamivir acts synergistically to inhibit human parainfluenza type-3 virus infection.…

Chris McGuigan (1958–2016)

A scientist who dedicated his life to drug discovery and was determined to nurture and grow life science and research in Wales.…

Treating Lyme disease: when will science catch up?

Cases of Lyme disease appear to be rising but there are still many unanswered questions about the condition, its diagnosis and the available treatment options.…

Curcumin boosts immune cell power against tuberculosis

Incubating cells with turmeric compound reduced Mycobacterium tuberculosis infection.…

COX-2 inhibitors might prevent pre-eclampsia

Cyclooxygenase (COX)-2 inhibitor celecoxib reversed early signs of pre-eclampsia in pregnant mice.…

Sperm activation finding could lead to new contraceptives

Enzyme that activates sperm mobility could lead to new contraceptives or treatment for male infertility.…