How critical illness impacts drug pharmacokinetics and pharmacodynamics

After reading this article, you should be able to:

• Understand the effects of critical illness on the pharmacokinetics and pharmacodynamics of commonly used drugs;
• Understand how to personalise drug therapy in critical illness according to the physiochemical properties of medicines, patient factors, disease factors and extracorporeal factors;
• Apply a conceptual framework for dosing strategies in critically ill patients.