‘Neurostatin’ prevents Alzheimer’s-related amyloid formation

Roundworm study shows bexarotene could inhibit early step of amyloid-beta aggregation.

Researchers have now found that the anti-cancer drug bexarotene could delay the formation of the most toxic form of amyloid-beta aggregates that cause Alzheimer's disease. In the image, amyloid plaques on neurones

A major therapeutic strategy for the prevention of Alzheimer’s disease is to inhibit the assembly of the disordered amyloid-beta peptide that aggregates in the brain. But no clinical trial to date has succeeded in this aim. 

In a previous study, researchers at the University of Cambridge identified some of the underlying molecular events that lead to amyloid-beta aggregation. Using this information, the team have now found that in a roundworm model, the anti-cancer drug bexarotene could inhibit the earliest step of the process and delay the formation of the most toxic form of amyloid-beta aggregates. But only if bexarotene is administered early. 

Reporting their findings in Science Advances (12 February 2016)[1]
, the team suggest that in future, drugs like bexarotene could be classed as ‘neurostatins’ and used in a preventive manner similar to statins for heart disease.

References

[1] Habchi J, Arosio P, Perni M et al.  An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Ab42 aggregates linked with Alzheimer’s disease. Science Advances 2016;2:e1501244. doi: 10.1126/sciadv.1501244

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Citation
Clinical Pharmacist, CP, March 2016, Vol 8, No 3;8(3):DOI:10.1211/PJ.2016.20200696