Drug-drug interactions

‘No evidence’ for some warnings of severe outcomes with antibiotics, say researchers

Researchers have called for the evidence base for the inclusion of drug interactions in national formularies to be "strengthened".…

Drug interaction may explain cannabidiol’s effects on severe form of epilepsy

A drug–drug interaction between cannabidiol and clobazam may explain why cannabidiol reduces the frequency of seizures in patients with a severe form of epilepsy, researchers have reported.…

Tamoxifen effectiveness not impaired by SSRIs

Researchers found no difference in mortality rates in women taking tamoxifen with paroxetine or fluoxetine compared with patients taking tamoxifen with other SSRIs.…

Study highlights drug-drug interaction risk from two commonly used drugs

Combined treatment with the antibiotic ceftriaxone and the proton pump inhibitor lansoprazole can lead to an increased risk of drug-induced arrhythmia, a study has found.…

OTC medicines can worsen heart failure, US cardiologists warn

The American Heart Association has highlighted the potential of some over-the-counter medicines to worsen heart failure.…

How polypharmacy has become a medical burden worldwide

More patients than ever are taking a multitude of medicines and supplements, but this can cause more harm than good.…

NICE tackles complex health issues for people with multimorbidity

The National Institute for Health and Care Excellence has issued draft guidance to help clinicians manage patients affected by multiple long-term health conditions.…

US study shows increase in risk of drug interactions

The proportion of older adults in the United States at risk of major drug-drug interactions increased from 8.4% to 15.1% over five years, according to an analysis published in JAMA Internal Medicine.…

Chronic Kidney Disease – Mineral and Bone Disorder: pathophysiology and treatment

How the pathophysiological mechanisms behind development of Chronic Kidney Disease - Mineral and Bone Disorder can be managed, using appropriate therapeutic interventions to prevent complications.…

Study highlights intracranial bleeding risk when antidepressants are taken with NSAIDs

Concomitant use of antidepressants and non-steroidal anti-inflammatory drugs is associated with an increased risk of intracranial haemorrhage, confirms new research.…