Drug-drug interactions

Study highlights intracranial bleeding risk when antidepressants are taken with NSAIDs

Concomitant use of antidepressants and non-steroidal anti-inflammatory drugs is associated with an increased risk of intracranial haemorrhage, confirms new research.…

The pros and cons of rat poison as medicine

Originally developed as a rat poison, warfarin has been used as an anticoagulant for over 60 years. But why is it so popular when alternatives are available?…

Mixing medicines: how to ensure patient safety

Incompatibility poses a constant risk when mixing medicines but it can be avoided by understanding the chemical reactions taking place.…

Clear and concise information on drug interactions

‘Stockley’s drug interactions 2015 pocket companion’, edited by Claire L Preston.…

Tizanidine interactions

Careful titration of the skeletal muscle relaxant tizanidine is required to avoid dose-related hypotension, and its serum levels can be increased by drugs that inhibit CYP1A2.…

Common antibiotic taken with a diuretic linked to sudden death

Spironolactone, a diuretic used to treat heart failure whose side effects include hyperkalaemia (raised blood potassium levels), is associated with an increased risk of sudden death when combined with the antibiotic trimethoprim–sulfamethoxazole.…

Ibrutinib launched for treatment of mantle cell lymphoma and chronic lymphocytic leukaemia

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, has been launched in the UK for the treatment of mantle cell lymphoma or chronic lymphocytic leukaemia.…

Canagliflozin and dapagliflozin interactions in diabetes treatment

Find out which interactions are associated with the latest antidiabetic medicines.…

Drug interactions and gout treatment

This case study looks at how the potential for drug interactions influences decision-making on the best treatment for gout…