Alzheimer’s drug development could be aided by multiple mouse-model validation Research suggests that GPR3, a receptor implicated in Alzheimer’s disease pathology, mediates disease progression and is a potential target for drug development.…
Breast cancer drug tamoxifen shows antimicrobial activity Tamoxifen, used for prevention and treatment of breast cancer, has been shown to enhance the antibacterial activity of white blood cells in a study published in Nature Communications.…
FAK inhibitors could allow immune system to attack cancer An experimental inhibitor of the cellular protein focal adhesion kinase helped the immune system to recognise and attack tumours in mice.…
Platelet-disguised nanoparticles could enhance drug delivery Nanoparticles coated in platelet membranes could be used to deliver drugs to sites around the body at lower doses than currently used.…
Small molecule halts preterm birth in mice Inflammation is associated with preterm birth, so researchers developed a small molecule that inhibits the proinflammatory cytokine interleukin 1 which is effective in a mouse model.…
Universal flu vaccine works in animals A new vaccine that targets a part of the influenza virus common to many viral strains has been developed and found to be effective in animal studies…
DNA vaccine protects against MERS infection In the efforts to prevent the spread of Middle East Respiratory Syndrome, researchers may have developed an effective new synthetic vaccine.…
Benefits of insulin in Alzheimer’s disease analysed in mouse study Researchers study mice to determine how insulin can improve symptoms of Alzheimer’s disease.…
Preclinical randomised controlled trials could tackle high attrition rates in drug development Researchers have come up with a potential solution to the problem of experimental drugs failing in clinical trials, despite promising results from preclinical, animal studies.…
Inflammation increases risk of hearing loss with antibiotic treatment Inflammation increases the risk of hearing loss associated with the use of aminoglycoside antibiotics, according to a study published in Science Translational Medicine.…
