Phase I research

Phase I trial volunteer dies as five others are hospitalised

One person has died and five more have been hospitalised after taking part in a phase I clinical trial in France.…

Q&A: Conducting an Ebola vaccine trial in Guinea in record time

John-Arne Røttingen tells his story about the Ebola vaccine trial in Guinea, made possible through an unforeseen international collaboration and elaborates on why further collaboration is needed in the future.…

Novel anti-platelet therapy shows promise in first human trials

New anti-platelet drug set for phase II study after success in patients with coronary heart disease.…

Filling the gap in mental health research

Ways to tackle the lack of funding in mental health research.…

Cancer drug shows promise for Parkinson’s disease

Patients with Parkinson’s disease were given the leukaemia drug nilotinib, which improved symptoms of the disease.…

Closing in on Alzheimer’s disease

Knowledge about the neuropathology of Alzheimer’s disease has blossomed over the past few decades, leading to a better understanding of the condition and new ways to attack it.…

Low risks to volunteers from phase I clinical drug trials, study shows

Fears over the risk of serious harms to volunteers in non-oncology phase I trials are unjustified, according to the results of a meta-analysis published in The BMJ.…

NICE’s assessment process is stifling pharmaceutical innovation

The way new medicines are assessed should be reformed to provide patients with the best treatments and stimulate research and innovation in the UK.…

Injection of modified cells reduces inflammation in arthritis sufferers

A single injection of a patient’s own modified dendritic cells appears to be safe and to have anti-inflammatory and immunoregulatory effects in rheumatoid arthritis.…

Drug development: the journey of a medicine from lab to shelf

Before a drug is deemed suitable for patients, it has to go through rigorous testing and cost-effectiveness analyses.…