Phase I research

Drug development: the journey of a medicine from lab to shelf

Before a drug is deemed suitable for patients, it has to go through rigorous testing and cost-effectiveness analyses.…

David Reddy: delivery of new anti-malaria drugs to developing countries is vital in fight against the disease

David Reddy, Medicines for Malaria Venture’s chief executive officer, discusses developments in the fight against the disease ahead of World Malaria Day on 25 April.…

Ebola vaccine based on 2014 virus strain is safe, trial shows

Chinese researchers have developed a recombinant adenovirus type-5 vector-based Ebola vaccine shown to be safe and “robustly immunogenic” in a phase I study.…

Tildrakizumab shows promise as psoriasis treatment

Merck reports in a phase I trial that its new monoclonal antibody, tildrakizumab, reduces psoriasis symptoms.…

Diuretic reduces skin atrophy associated with corticosteroid creams

Spironolactone, used to treat fluid retention in patients with oedema, heart failure and hypertension, can also alleviate side effects from corticosteroid-based creams used for certain skin conditions, according to research.…

Researchers develop test that predicts severe immune reaction to biologics

A test that uses cells from a single donor’s blood to predict whether a new drug will cause a severe immune reaction in humans has been developed by researchers at Imperial College London.…

AstraZeneca spins out early-stage R&D for antibiotic compounds

AstraZeneca is creating a standalone subsidiary to work exclusively on early-stage antibiotics research and development, the company has announced.…

Malaria eradication: blocking transmission to mosquitoes

To wipe out malaria, researchers are racing to develop a vaccine that protects mosquitoes from infection.…

Ebola clinical trial suspended after volunteers complain of joint pains

A phase I clinical trial of the fast-tracked Ebola vaccine VSV-ZEBOV has been halted in Switzerland because some trial participants developed mild joint pain.…

Phase I trial of GlaxoSmithKline’s Ebola vaccine shows it is well tolerated

No major adverse events were reported in an Ebola vaccine phase I trial involving 20 volunteers.…