Gastrointestinal agents

SSRIs used for menopausal symptoms may increase bone fracture risk

$Middle-aged women who take antidepressant selective serotonin reuptake inhibitors (SSRIs) to treat menopausal symptoms may “significantly” increase their risk of bone fracture. In the image, film x-ray that show a distal radius fracture$

Middle-aged women who take antidepressant selective serotonin reuptake inhibitors to treat menopausal symptoms may “significantly” increase their risk of bone fracture.…

Acid-reducing drugs could increase risk of bacterial infection in children

Acid suppression medication is associated with Clostridium difficile infection (CDI) in infants and children aged up to 17 years in an outpatient setting, researchers found in a population-based study.…

Proton pump inhibitors are associated with increased risk of heart attack

Data mining research shows common heartburn drugs are linked to cardiovascular events.…

Patients with systemic sclerosis have higher levels of inflammatory gut bacteria

Patients with the autoimmune disorder systemic sclerosis have a unique microbiome pattern in their gut, suggests research presented at the Annual European Congress of Rheumatology.…

Review collates evidence on increased risk of death for anticholinergics

A new systematic review and meta-analysis suggests that patients using any drug with anticholinergic effects have a 45% increased risk of cognitive impairment.…

FDA approves two new drugs for irritable bowel syndrome

The US Food and Drug Administration has approved two new treatments for patients with irritable bowel syndrome with diarrhoea.…

Study provides insight into why PPI users benefit from calcium supplements

$Proton pump inhibitors (PPIs) are associated with an increased risk of bone fracture, but the underlying mechanisms are poorly understood. In the image, x-ray of a fractured wrist$

Researchers have identified a gene, Snx10, whose expression is required both in the bone and stomach to maintain normal gastric acidification and calcium absorption.…

Linaclotide, lubiprostone and prucalopride interactions

How to avoid potential pharmacokinetic and pharmacodynamic interactions with the latest medicines for managing constipation.…

Step into the limelight – pharmacists to take the lead in advancing the management of acid reflux

So, step into the limelight! In this article we review the current thinking in the management of heartburn and acid reflux in community pharmacies, and provide guidance and practical tools for the entire pharmacy team to support a customer-centric approach to care.…

Constipation: managing the condition in adults

How to assess patients with constipation and select the right treatment to minimise the risk of complications.…