Research challenges ‘cytokine storm’ hypothesis of Alzheimer’s disease Interleukin-10 – an anti-inflammatory cytokine – has detrimental effects in a mouse model of Alzheimer’s disease (AD), challenging the “cytokine storm” hypothesis of AD progression.…
AstraZeneca’s CRISPR collaborations aim to identify drug targetsAstraZeneca has announced four research collaborations that will use CRISPR, a pioneering genome-editing technique, to identify and validate potential drug targets.…
Sestrin 3 gene regulates convulsions in epilepsy Researchers analysed hippocampal brain tissue samples from 129 people with temporal lobe epilepsy and found that genetic control of convulsions was due to a single gene.…
Anti-VEGF therapies could have role in treating TB Bevacizumab, an anti-VEGF drug, was able to normalise granuloma vasculature, improve the delivery of small molecules and decrease hypoxia in a rabbit model of tuberculosis.…
Structure of translocator protein hints at role in disease Two research groups have independently solved the structures of similar translocator proteins, offering clues about its function that could spur the development of targeted drugs.…
Cholic acid named ‘Golden Pill’ in Prescrire’s annual awards‘A drug used to treat children with a rare genetic condition who are unable to produce bile and risk fatal liver failure has received international recognition.…
Study shows how glucocorticoids tightly control the inflammatory response IRAK-M, a key negative regulator of inflammatory pathways, may represent a new therapeutic target to suppress bacteria-induced inflammation, say researchers.…
Latest advances in hepatitis C therapy The availability of new protease inhibitors is revolutionising the treatment of hepatitis C virus infection.…
Human Protein Atlas reveals drug targets The Human Protein Atlas shows the locations of almost 17,000 different proteins in the human body and could offer invaluable guidance for drug developers. …
How pork and bacon could be used in medical procedures Pork and bacon have proved themselves to be useful tools in treating nosebleeds and parasitic infections.…
